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Joseph A. Hirsch
,
Steven Mandel
,
Kurt T. Hegmann
,
Alexandra G. Stratyner
,
Stuart Gitlow
,
James B. Talmage
, and
Christopher R. Brigham
from 2020. More than 70% of these fatalities were caused by opioid overdose, most involving synthetic opioids other than methadone. Cocaine and psychostimulants also contributed to increasing drug overdose deaths (approximately 17% of the total in 2021). For the first half of 2020, there were almost 3,000 fatal overdoses owing to benzodiazepines, with 92.7% also involving opioids. 3 The enormous surge in morbidity and mortality associated with drug use and addiction piqued our curiosity. The characterization of drug addiction as a chronic, relapsing disease of the
